Dissemination of polymeric waste in the environment is one of the most important concerns of the world today. Used plastics and worn tires are one of the most important sources of this type of waste. Chemically, these materials are very similar to bitumen as the most used and expensive component of asphalt mixtures. Therefore, using these waste materials as an additive in bitumen while reducing environmental pollution can improve the performance characteristics of the pavement. Investigating the effect of each type of additive on the fatigue performance of asphalt mixture is essential as one of the most important factors in causing pavement damage. Therefore, in this research, in addition to examining the physical properties of bitumen, the fatigue performance of asphalt mixture containing different percentages of waste plastic and rubber powder has been investigated using the four-point bending beam method. The results of this test using the hardness method, Normalized hardness and energy method were analyzed. The results showed that waste plastic reduced the fatigue resistance of the asphalt mixture, which was compensated to a significant extent by adding rubber powder. So that the samples containing rubber powder and waste plastic at the same time had a longer fatigue life than the control sample.